| Gene Information | |
|---|---|
| Gene Name | ADAM12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 909 |
| Protein Names | Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000148848 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43184 |
| Gene Card | ADAM12 |
| Uniprot ID | O43184 |
| Pfam | PF08516; PF00200; PF01562; PF01421 |
| In ASD | no |
| Allosteric Prediction | no (-0.127690691) |
| Ortholog in Animals | Alpaca_ ADAM12 ( ortholog_one2one ) Dog_ ADAM12 ( ortholog_one2one ) GuineaPig_ ADAM12 ( ortholog_one2one ) Macaque_ ADAM12 ( ortholog_one2one ) Mouse_ Adam12 ( ortholog_one2one ) Pig_ ADAM12 ( ortholog_one2one ) Rat_ Adam12 ( ortholog_one2one ) Rabbit_ ADAM12 ( ortholog_one2one ) |
| Ohnologs | ADAM33, ADAM28, ADAM7, ADAM2, ADAM30, ADAM19, ADAM29, ADAM9, ADAM18, ADAM32 |
| Paralogs | ADAM20, ADAM33, ADAM19, ADAM17, ADAM9, ADAM28, ADAM32, ADAM21, ADAM22, ADAM2, ADAM10, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM8, ADAM11 |
| Tissue | placenta |
| Tissue Specificity | Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3740199 rs1459457663 rs151030407 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted {ECO:0000305}.; [Isoform 4]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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