| Gene Information | |
|---|---|
| Gene Name | FGR |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) |
| Target Name | tyrosine-protein kinase fgr |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000000938 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P09769 |
| Gene Card | FGR |
| Uniprot ID | P09769 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (1.106549262) |
| Ortholog in Animals | Alpaca_ FGR ( ortholog_one2many ) Dog_ FGR ( ortholog_one2one ) GuineaPig_ FGR ( ortholog_one2one ) Macaque_ FGR ( ortholog_one2one ) Mouse_ Fgr ( ortholog_one2one ) Pig_ FGR ( ortholog_one2one ) Rat_ Fgr ( ortholog_one2one ) Rabbit_ FGR ( ortholog_one2one ) |
| Ohnologs | FYN, HCK, FRK, BLK, YES1, SRC |
| Paralogs | FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. {ECO:0000269|PubMed:11078731, ECO:0000269|PubMed:2181286, ECO:0000269|PubMed:8327512}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7JT9 (X-ray 1.93A ) |
| DBSNP | rs34597831 rs35334091 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. {ECO:0000250}. |
| Mouse PG classification | NA |
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