| Gene Information | |
|---|---|
| Gene Name | ADA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Adenosine deaminase 2 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000093072 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZK5 |
| Gene Card | ADA2 |
| Uniprot ID | Q9NZK5 |
| Pfam | PF00962; PF08451 |
| In ASD | no |
| Allosteric Prediction | yes (0.652006777) |
| Ortholog in Animals | Alpaca_ ADA2 ( ortholog_one2one ) Macaque_ ADA2 ( ortholog_one2one ) Pig_ ADA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADAL, ADA |
| Tissue | NA |
| Tissue Specificity | Detected in blood plasma (at protein level). Widely expressed, with most abundant expression in human adult heart, lung, lymphoblasts, and placenta as well as fetal lung, liver, and kidney. In embryo, expressed in the outflow tract and atrium of the developing heart, the VII/VIII cranial nerve ganglion, and the notochord. {ECO:0000269|PubMed:15926889}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3LGD (X-ray 2.00A ) 3LGG (X-ray 2.50A ) |
| DBSNP | rs202134424 rs200930463 rs587777240 rs587777241 rs77563738 rs148936893 rs587777242 rs2231495 rs376785840 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15926889, ECO:0000269|PubMed:20147294, ECO:0000269|PubMed:20453107}. |
| Mouse PG classification | NA |
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