| Gene Information | |
|---|---|
| Gene Name | PLCG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1290 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000124181 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P19174 |
| Gene Card | PLCG1 |
| Uniprot ID | P19174 |
| Pfam | PF00168; PF00388; PF00387; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999700624) |
| Ortholog in Animals | Alpaca_ PLCG1 ( ortholog_one2one ) Dog_ PLCG1 ( ortholog_one2one ) GuineaPig_ PLCG1 ( ortholog_one2one ) Macaque_ PLCG1 ( ortholog_one2one ) Mouse_ Plcg1 ( ortholog_one2one ) Pig_ PLCG1 ( ortholog_one2one ) Rat_ Plcg1 ( ortholog_one2one ) Rabbit_ PLCG1 ( ortholog_one2one ) |
| Ohnologs | PLCG2 |
| Paralogs | PLCG2, PLCD3, PLCB3, PLCE1, PLCB1, PLCD4, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.093901(Chimpanzee);0.008696(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1HSQ (NMR - ) 2HSP (NMR - ) 4EY0 (X-ray 2.80A ) 4FBN (X-ray 2.40A ) 7NXE (X-ray 2.10A ) |
| DBSNP | rs2229348 rs2228246 rs34203315 rs753381 |
| Subcellular location [CC] | Cell projection, lamellipodium {ECO:0000269|PubMed:17229814}. Cell projection, ruffle {ECO:0000269|PubMed:17229814}. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. {ECO:0000269|PubMed:17229814}. |
| Mouse PG classification | NA |
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