Gene Information
Gene NameADA
OrganismHomo sapiens (Human)
Gene Length363
Protein NamesAdenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
Target Nameadenosine deaminase
Target TypeSuccessful target
Gene Age1714 ( ENSG00000196839 )
Evolutionary StageEuk+Bac
AlphaFoldDBP00813
Gene CardADA
Uniprot IDP00813
PfamPF00962
In ASDno
Allosteric Predictionyes (1.361767087)
Ortholog in AnimalsAlpaca_ ADA ( ortholog_one2one )
Dog_ ADA ( ortholog_one2one )
GuineaPig_ ADA ( ortholog_one2one )
Macaque_ ADA ( ortholog_one2one )
Mouse_ Ada ( ortholog_one2one )
Pig_ ADA ( ortholog_one2one )
Rat_ Ada ( ortholog_one2one )
Rabbit_ ADA ( ortholog_one2one )
OhnologsNA
ParalogsADAL, ADA2
Tissuesmall.intestine
Tissue SpecificityFound in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. {ECO:0000269|PubMed:20959412}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3IAR  (X-ray  1.52A  )  7RTG  (X-ray  2.59A  ) 
DBSNP rs73598374  rs121908725  rs121908724  rs121908730  rs121908736  rs11555566  rs121908726  rs267606634  rs121908714  rs121908714  rs121908717  rs267606635  rs121908739  rs121908731  rs121908732  rs61732239  rs121908737  rs121908733  rs121908728  rs121908735  rs121908722  rs121908719  rs121908727  rs121908734  rs121908740  rs121908716  rs114025668  rs121908723  rs121908729  rs121908738  rs121908721  rs121908718  rs199422327  rs121908715 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:8101391};
Peripheral membrane protein;
Extracellular side. Cell junction {ECO:0000269|PubMed:11772392}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000269|PubMed:8452534}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000269|PubMed:11772392}.
Mouse PG classificationLPG
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