| Gene Information | |
|---|---|
| Gene Name | ADA |
| Organism | Homo sapiens (Human) |
| Gene Length | 363 |
| Protein Names | Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) |
| Target Name | adenosine deaminase |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000196839 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00813 |
| Gene Card | ADA |
| Uniprot ID | P00813 |
| Pfam | PF00962 |
| In ASD | no |
| Allosteric Prediction | yes (1.361767087) |
| Ortholog in Animals | Alpaca_ ADA ( ortholog_one2one ) Dog_ ADA ( ortholog_one2one ) GuineaPig_ ADA ( ortholog_one2one ) Macaque_ ADA ( ortholog_one2one ) Mouse_ Ada ( ortholog_one2one ) Pig_ ADA ( ortholog_one2one ) Rat_ Ada ( ortholog_one2one ) Rabbit_ ADA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADAL, ADA2 |
| Tissue | small.intestine |
| Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. {ECO:0000269|PubMed:20959412}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3IAR (X-ray 1.52A ) 7RTG (X-ray 2.59A ) |
| DBSNP | rs73598374 rs121908725 rs121908724 rs121908730 rs121908736 rs11555566 rs121908726 rs267606634 rs121908714 rs121908714 rs121908717 rs267606635 rs121908739 rs121908731 rs121908732 rs61732239 rs121908737 rs121908733 rs121908728 rs121908735 rs121908722 rs121908719 rs121908727 rs121908734 rs121908740 rs121908716 rs114025668 rs121908723 rs121908729 rs121908738 rs121908721 rs121908718 rs199422327 rs121908715 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:8101391}; Peripheral membrane protein; Extracellular side. Cell junction {ECO:0000269|PubMed:11772392}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000269|PubMed:8452534}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000269|PubMed:11772392}. |
| Mouse PG classification | LPG |
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