| Gene Information | |
|---|---|
| Gene Name | TNFAIP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145779 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O95379 |
| Gene Card | TNFAIP8 |
| Uniprot ID | O95379 |
| Pfam | PF05527 |
| In ASD | no |
| Allosteric Prediction | no (-1.201184705) |
| Ortholog in Animals | Alpaca_ TNFAIP8 ( ortholog_one2one ) Dog_ TNFAIP8 ( ortholog_one2one ) GuineaPig_ TNFAIP8 ( ortholog_one2one ) Mouse_ Tnfaip8 ( ortholog_one2one ) Pig_ TNFAIP8 ( ortholog_one2one ) Rat_ Tnfaip8 ( ortholog_one2one ) |
| Ohnologs | TNFAIP8L3, TNFAIP8L1, TNFAIP8L2 |
| Paralogs | TNFAIP8L1, TNFAIP8L3, TNFAIP8L2 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. {ECO:0000269|PubMed:10233894, ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:14724590}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3203922 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14724590}. |
| Mouse PG classification | NA |
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