Gene Information
Gene NameANTXR2
OrganismHomo sapiens (Human)
Gene Length489
Protein NamesAnthrax toxin receptor 2 (Capillary morphogenesis gene 2 protein) (CMG-2)
Target Nameanthrax toxin receptor 2
Target TypeNA
Gene Age645 ( ENSG00000163297 )
Evolutionary StageEumetazoa
AlphaFoldDBP58335
Gene CardANTXR2
Uniprot IDP58335
PfamPF05586; PF05587; PF00092
In ASDno
Allosteric Predictionno (-0.634931076)
Ortholog in AnimalsAlpaca_ ANTXR2 ( ortholog_one2one )
Dog_ ANTXR2 ( ortholog_one2one )
GuineaPig_ ANTXR2 ( ortholog_one2one )
Macaque_ ANTXR2 ( ortholog_one2one )
Mouse_ Antxr2 ( ortholog_one2one )
Pig_ ANTXR2 ( ortholog_one2one )
Rat_ Antxr2 ( ortholog_one2one )
Rabbit_ ANTXR2 ( ortholog_one2one )
OhnologsANTXR1
ParalogsANTXRL, ANTXR1
TissueNA
Tissue SpecificityExpressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. {ECO:0000269|PubMed:14508707}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1SHT  (X-ray  1.81A  )  1SHU  (X-ray  1.50A  )  1T6B  (X-ray  2.50A  )  1TZN  (X-ray  4.30A  )  7N1O  (X-ray  2.77A  ) 
DBSNP rs886041401  rs137852902  rs137852905  rs781637328  rs137852903  rs12647691  rs137852901 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000269|PubMed:12700348};
Single-pass type I membrane protein {ECO:0000255}. Note=Expressed at the cell surface. {ECO:0000269|PubMed:12700348}.;
[Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11683410};
Single-pass type I membrane protein {ECO:0000255}. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane. {ECO:0000269|PubMed:11683410}.;
[Isoform 3]: Secreted {ECO:0000305}.
Mouse PG classificationLPG
click here to return to the previous page