| Gene Information | |
|---|---|
| Gene Name | ACTR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Actin-related protein 3 (Actin-like protein 3) |
| Target Name | actin-related protein 3 |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000115091 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P61158 |
| Gene Card | ACTR3 |
| Uniprot ID | P61158 |
| Pfam | PF00022 |
| In ASD | yes |
| Allosteric Prediction | yes (0.955031782) |
| Ortholog in Animals | Alpaca_ ACTR3 ( ortholog_one2one ) GuineaPig_ ACTR3 ( ortholog_one2one ) Macaque_ ACTR3 ( ortholog_one2one ) Mouse_ Actr3 ( ortholog_one2one ) Pig_ ACTR3 ( ortholog_one2one ) Rat_ Actr3 ( ortholog_one2one ) |
| Ohnologs | ACTR3B |
| Paralogs | ACTC1, ACTBL2, ACTR1A, ACTB, ACTG1, ACTR5, ACTL9, ACTL7A, ACTL7B, ACTL8, ACTA1, ACTL6B, ACTR3B, ACTR3C, ACTRT2, ACTR8, ACTR1B, ACTL6A, ACTR2, ACTR6, ACTRT1, ACTRT3, ACTL10, ACTG2, ACTA2, ACTR10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.067323(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6UHC (EM 3.90A ) 6YW6 (EM 4.20A ) 6YW7 (EM 4.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19109554}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29925947}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554). |
| Mouse PG classification | NA |
| click here to return to the previous page | |