Gene Information
Gene NameACTN3
OrganismHomo sapiens (Human)
Gene Length901
Protein NamesAlpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Target NameNA
Target TypeNA
Gene Age168 ( ENSG00000248746 )
Evolutionary StageEukaryota
AlphaFoldDBQ08043
Gene CardACTN3
Uniprot IDQ08043
PfamPF00307; PF08726; PF00435
In ASDno
Allosteric Predictionyes (0.462763104)
Ortholog in AnimalsAlpaca_ ACTN3 ( ortholog_one2one )
Dog_ ACTN3 ( ortholog_one2one )
GuineaPig_ ACTN3 ( ortholog_one2one )
Macaque_ ACTN3 ( ortholog_one2one )
Mouse_ Actn3 ( ortholog_one2one )
Pig_ ACTN3 ( ortholog_one2one )
Rat_ Actn3 ( ortholog_one2one )
Rabbit_ ACTN3 ( ortholog_one2one )
OhnologsNA
ParalogsACTN2, DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, PLEC, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4
Tissueskeletal.muscle, artery
Tissue SpecificityExpressed only in a subset of type 2 skeletal muscle fibers. {ECO:0000269|PubMed:11440986}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1TJT  (X-ray  2.19A  1WKU  (X-ray  1.60A  3LUE  (EM 
DBSNP rs1671064  rs618838  rs2229456  rs540874 
Subcellular location [CC]NA
Mouse PG classificationNA
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