Gene Information
Gene NameIL31RA
OrganismHomo sapiens (Human)
Gene Length732
Protein NamesInterleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
Target Nameinterleukin 31 receptor
Target TypeClinical trial target
Gene Age645 ( ENSG00000164509 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8NI17
Gene CardIL31RA
Uniprot IDQ8NI17
PfamPF00041; PF09240
In ASDno
Allosteric Predictionno (-0.489929248)
Ortholog in AnimalsAlpaca_ IL31RA ( ortholog_one2one )
Dog_ IL31RA ( ortholog_one2one )
GuineaPig_ IL31RA ( ortholog_one2one )
Macaque_ IL31RA ( ortholog_one2one )
Mouse_ Il31ra ( ortholog_one2one )
Pig_ IL31RA ( ortholog_one2one )
Rat_ Il31ra ( ortholog_one2one )
Rabbit_ IL31RA ( ortholog_one2one )
OhnologsIL12RB2
ParalogsCRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR
TissueNA
Tissue SpecificityExpressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353). {ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:16461143, ECO:0000269|PubMed:18439099, ECO:0000269|PubMed:21261663, ECO:0000269|PubMed:24373353}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs13184107  rs161704 
Subcellular location [CC]Cell membrane {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285};
Single-pass type I membrane protein {ECO:0000305|PubMed:11877449, ECO:0000305|PubMed:14504285}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8K5B1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K5B1}.
Mouse PG classificationLPG
click here to return to the previous page