| Gene Information | |
|---|---|
| Gene Name | ACTB |
| Organism | Homo sapiens (Human) |
| Gene Length | 375 |
| Protein Names | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] |
| Target Name | actin, cytoplasmic 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000075624 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P60709 |
| Gene Card | ACTB |
| Uniprot ID | P60709 |
| Pfam | PF00022 |
| In ASD | no |
| Allosteric Prediction | yes (0.91952971) |
| Ortholog in Animals | Alpaca_ ACTB ( ortholog_one2one ) Dog_ ACTB ( ortholog_one2one ) GuineaPig_ ACTB ( ortholog_one2one ) Macaque_ ACTB ( ortholog_one2one ) Mouse_ Actb ( ortholog_one2one ) Pig_ ACTB ( ortholog_one2one ) Rat_ Actb ( ortholog_one2one ) |
| Ohnologs | ACTG1 |
| Paralogs | ACTG1, ACTC1, ACTBL2, ACTR1A, ACTR5, ACTL9, ACTR3, ACTL7A, ACTL7B, ACTL8, ACTA1, ACTL6B, ACTR3B, ACTR3C, ACTRT2, ACTR8, ACTR1B, ACTL6A, ACTR2, ACTR6, ACTRT1, ACTRT3, ACTL10, ACTG2, ACTA2, ACTR10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3BYH (EM 12.00A ) 3D2U (X-ray 2.21A ) 3J82 (EM 7.70A ) 3LUE (EM - ) 6ANU (EM 7.00A ) 6ICT (X-ray 1.95A ) 6ICV (X-ray 2.15A ) 6LTJ (EM 3.70A ) 6MBJ (X-ray 1.78A ) 6MBK (X-ray 1.69A ) 6MBL (X-ray 2.20A ) 6NBW (X-ray 2.50A ) 6OX0 (X-ray 1.75A ) 6OX1 (X-ray 1.95A ) 6OX2 (X-ray 2.09A ) 6OX3 (X-ray 1.78A ) 6OX4 (X-ray 2.29A ) 6OX5 (X-ray 2.10A ) 6V62 (X-ray 2.36A ) 6V63 (X-ray 2.02A ) 6WK1 (X-ray 1.89A ) 6WK2 (X-ray 1.76A ) 7AS4 (EM 4.13A ) 7P1H (EM 3.90A ) 7VDV (EM 3.40A ) |
| DBSNP | rs281875331 rs281875332 rs104894003 rs281875333 rs281875334 rs11546899 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}. |
| Mouse PG classification | LPG |
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