| Gene Information | |
|---|---|
| Gene Name | ACTA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] |
| Target Name | actin, alpha skeletal muscle |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000143632 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P68133 |
| Gene Card | ACTA1 |
| Uniprot ID | P68133 |
| Pfam | PF00022 |
| In ASD | yes |
| Allosteric Prediction | yes (1.144949711) |
| Ortholog in Animals | Alpaca_ ACTA1 ( ortholog_one2one ) GuineaPig_ ACTA1 ( ortholog_one2one ) Macaque_ ACTA1 ( ortholog_one2one ) Mouse_ Acta1 ( ortholog_one2one ) Pig_ ACTA1 ( ortholog_one2one ) Rat_ Acta1 ( ortholog_one2one ) Rabbit_ ACTA1 ( ortholog_one2one ) |
| Ohnologs | ACTA2, ACTC1, ACTG2 |
| Paralogs | ACTC1, ACTBL2, ACTR1A, ACTB, ACTG1, ACTR5, ACTL9, ACTR3, ACTL7A, ACTL7B, ACTL8, ACTL6B, ACTR3B, ACTR3C, ACTRT2, ACTR8, ACTR1B, ACTL6A, ACTR2, ACTR6, ACTRT1, ACTRT3, ACTL10, ACTG2, ACTA2, ACTR10 |
| Tissue | heart, skeletal.muscle |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001212(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7RNS (X-ray 1.14A ) 7RNU (X-ray 1.45A ) 7RNV (X-ray 2.15A ) |
| DBSNP | rs121909527 rs121909521 rs1553255521 rs1659984269 rs398123562 rs1553255502 rs1659978909 rs121909519 rs1659975747 rs121909520 rs121909526 rs1553255482 rs121909522 rs121909522 rs1064794287 rs1064794287 rs869312739 rs121909530 rs1057521118 rs794727714 rs367543051 rs1659954634 rs121909523 rs121909525 rs121909525 rs1553255360 rs1553255357 rs121909529 rs398122936 rs121909531 rs121909528 rs587777354 rs121909524 rs1571892209 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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