Gene Information
Gene NameRGS7
OrganismHomo sapiens (Human)
Gene Length495
Protein NamesRegulator of G-protein signaling 7 (RGS7)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000182901 )
Evolutionary StageEumetazoa
AlphaFoldDBP49802
Gene CardRGS7
Uniprot IDP49802
PfamPF00610; PF00631; PF00615; PF18148
In ASDno
Allosteric Predictionno (-0.134102718)
Ortholog in AnimalsAlpaca_ RGS7 ( ortholog_one2one )
Dog_ RGS7 ( ortholog_one2one )
GuineaPig_ RGS7 ( ortholog_one2one )
Macaque_ RGS7 ( ortholog_one2one )
Mouse_ Rgs7 ( ortholog_one2one )
Pig_ RGS7 ( ortholog_one2one )
Rat_ Rgs7 ( ortholog_one2one )
Rabbit_ RGS7 ( ortholog_one2one )
OhnologsRGS9, RGS6
ParalogsRGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS12, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10
Tissuebrain, cerebral.cortex, caudate.nucleus, cerebellar.hemisphere, cerebellum, nucleus.accumbens, putamen
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2A72  (X-ray  2.00A  )  2D9J  (NMR  -  )  7EWP  (EM  4.30A  )  7EWR  (EM  4.70A  )  7SHF  (EM  3.40A  ) 
DBSNP rs12746550  rs17851953 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Cytoplasm {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Cell membrane {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Membrane {ECO:0000269|PubMed:10521509};
Peripheral membrane protein {ECO:0000269|PubMed:10521509};
Cytoplasmic side {ECO:0000305}. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264). {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}.
Mouse PG classificationNA
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