| Gene Information | |
|---|---|
| Gene Name | NCAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 858 |
| Protein Names | Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) |
| Target Name | neural cell adhesion molecule 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000149294 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P13591 |
| Gene Card | NCAM1 |
| Uniprot ID | P13591 |
| Pfam | PF00041; PF07679 |
| In ASD | no |
| Allosteric Prediction | yes (0.643281224) |
| Ortholog in Animals | Alpaca_ NCAM1 ( ortholog_one2one ) Dog_ NCAM1 ( ortholog_one2one ) GuineaPig_ NCAM1 ( ortholog_one2one ) Macaque_ NCAM1 ( ortholog_one2one ) Mouse_ Ncam1 ( ortholog_one2one ) Pig_ NCAM1 ( ortholog_one2one ) Rat_ Ncam1 ( ortholog_one2one ) Rabbit_ NCAM1 ( ortholog_one2one ) |
| Ohnologs | NCAM2 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | substantia.nigra |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E3V (X-ray 1.95A ) 2HAZ (X-ray 1.70A ) 2VKW (X-ray 2.30A ) 2VKX (X-ray 2.70A ) 3MTR (X-ray 1.80A ) 5AEA (X-ray 1.90A ) 5LKN (NMR - ) |
| DBSNP | rs7105734 rs17115160 rs17115280 rs17174409 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 4]: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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