Gene Information
Gene NameACP3
OrganismHomo sapiens (Human)
Gene Length386
Protein NamesProstatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]
Target NameNA
Target TypeNA
Gene Age424 ( ENSG00000014257 )
Evolutionary StageEukaryota
AlphaFoldDBP15309
Gene CardACP3
Uniprot IDP15309
PfamPF00328
In ASDno
Allosteric Predictionno (-0.177957119)
Ortholog in AnimalsAlpaca_ ACP3 ( ortholog_one2one )
Dog_ ACP3 ( ortholog_one2one )
GuineaPig_ ACP3 ( ortholog_one2one )
Macaque_ ACP3 ( ortholog_one2one )
Mouse_ Acpp ( ortholog_one2one )
Pig_ ACP3 ( ortholog_one2one )
Rat_ Acp3 ( ortholog_one2one )
Rabbit_ ACP3 ( ortholog_one2one )
OhnologsACP2, ACP4
ParalogsACP2, ACP4, FRA10AC1, ACP6, PXYLP1
Tissueprostate
Tissue SpecificityHighly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues. {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:21487525}.;
[Isoform 2]: Widely expressed. Expressed in the sarcolemma of skeletal muscle. {ECO:0000269|PubMed:17638863}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CVI  (X-ray  3.20A  )  1ND5  (X-ray  2.90A  )  1ND6  (X-ray  2.40A  )  2HPA  (X-ray  2.90A  )  2L3H  (NMR  -  )  2L77  (NMR  -  )  2L79  (NMR  -  )  2MG0  (NMR  -  )  3PPD  (X-ray  1.50A  )  7ZZV  (NMR  -  ) 
DBSNP rs17850347  rs17856254  rs17856253  rs17851392  rs17850198 
Subcellular location [CC][Isoform 1]: Secreted {ECO:0000305|PubMed:17638863}.;
[Isoform 2]: Cell membrane {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20498373};
Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319};
Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:20498373}. Cytoplasm, cytosol {ECO:0000269|PubMed:20498373}. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). {ECO:0000269|PubMed:17638863, ECO:0000269|PubMed:17897319}.
Mouse PG classificationNA
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