| Gene Information | |
|---|---|
| Gene Name | ACOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 660 |
| Protein Names | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] |
| Target Name | peroxisomal acyl-coenzyme a oxidase 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000161533 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q15067 |
| Gene Card | ACOX1 |
| Uniprot ID | Q15067 |
| Pfam | PF01756; PF02770; PF14749 |
| In ASD | no |
| Allosteric Prediction | yes (0.418570458) |
| Ortholog in Animals | Alpaca_ ACOX1 ( ortholog_one2one ) Dog_ ACOX1 ( ortholog_one2one ) GuineaPig_ ACOX1 ( ortholog_one2one ) Macaque_ ACOX1 ( ortholog_one2one ) Mouse_ Acox1 ( ortholog_one2one ) Pig_ ACOX1 ( ortholog_one2one ) Rat_ Acox1 ( ortholog_one2one ) Rabbit_ ACOX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACAD11, ACADM, ACAD9, IVD, GCDH, ACOXL, ACAD10, ACADS, ACOX3, ACAD8, ACOX2, ACADVL, ACADSB, ACADL |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. {ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:20195242}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3744032 rs17855420 rs118204091 rs780887410 rs1567876984 rs118204090 rs118204092 rs758962364 rs1135640 |
| Subcellular location [CC] | Peroxisome {ECO:0000269|PubMed:32169171}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |