| Gene Information | |
|---|---|
| Gene Name | ACOT8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 319 |
| Protein Names | Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.1) (EC 3.1.2.11) (EC 3.1.2.2) (EC 3.1.2.3) (EC 3.1.2.5) (Choloyl-coenzyme A thioesterase) (EC 3.1.2.27) (HIV-Nef-associated acyl-CoA thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) (Thioesterase II) (hACTE-III) (hACTEIII) (hTE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000101473 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14734 |
| Gene Card | ACOT8 |
| Uniprot ID | O14734 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.000020595) |
| Ortholog in Animals | Alpaca_ ACOT8 ( ortholog_one2one ) Dog_ ACOT8 ( ortholog_one2one ) GuineaPig_ ACOT8 ( ortholog_one2one ) Macaque_ ACOT8 ( ortholog_one2one ) Mouse_ Acot8 ( ortholog_one2one ) Pig_ ACOT8 ( ortholog_one2one ) Rat_ Acot8 ( ortholog_one2one ) Rabbit_ ACOT8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in a T-cell line (at protein level). Ubiquitous (PubMed:9153233, PubMed:9299485). {ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Peroxisome matrix {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. |
| Mouse PG classification | NA |
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