| Gene Information | |
|---|---|
| Gene Name | ACOD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 481 |
| Protein Names | Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000102794 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | A6NK06 |
| Gene Card | ACOD1 |
| Uniprot ID | A6NK06 |
| Pfam | PF03972; PF19305 |
| In ASD | no |
| Allosteric Prediction | no (-0.147826457) |
| Ortholog in Animals | Alpaca_ ACOD1 ( ortholog_one2one ) Dog_ ACOD1 ( ortholog_one2one ) GuineaPig_ ACOD1 ( ortholog_one2one ) Macaque_ ACOD1 ( ortholog_one2one ) Mouse_ Acod1 ( ortholog_one2one ) Pig_ ACOD1 ( ortholog_one2one ) Rat_ Acod1 ( ortholog_one2one ) Rabbit_ ACOD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6R6U (X-ray 1.71A ) |
| DBSNP | rs767323284 rs1471882722 rs1018207074 rs1289708092 rs755737247 |
| Subcellular location [CC] | Mitochondrion {ECO:0000250|UniProtKB:P54987}. |
| Mouse PG classification | NA |
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