| Gene Information | |
|---|---|
| Gene Name | ACO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 889 |
| Protein Names | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000122729 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P21399 |
| Gene Card | ACO1 |
| Uniprot ID | P21399 |
| Pfam | PF00330; PF00694 |
| In ASD | no |
| Allosteric Prediction | yes (0.413845842) |
| Ortholog in Animals | Alpaca_ ACO1 ( ortholog_one2one ) Dog_ ACO1 ( ortholog_one2one ) GuineaPig_ ACO1 ( ortholog_one2one ) Macaque_ ACO1 ( ortholog_one2one ) Mouse_ Aco1 ( ortholog_one2one ) Pig_ ACO1 ( ortholog_one2one ) Rat_ Aco1 ( ortholog_one2one ) Rabbit_ ACO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IREB2, ACO2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B3X (X-ray 2.54A ) 2B3Y (X-ray 1.85A ) |
| DBSNP | rs150373174 rs3814519 rs34630459 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:1281544}. |
| Mouse PG classification | NA |
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