| Gene Information | |
|---|---|
| Gene Name | ACLY |
| Organism | Homo sapiens (Human) |
| Gene Length | 1101 |
| Protein Names | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) |
| Target Name | atp-citrate synthase |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000131473 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53396 |
| Gene Card | ACLY |
| Uniprot ID | P53396 |
| Pfam | PF16114; PF00285; PF02629; PF00549 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000025454) |
| Ortholog in Animals | Alpaca_ ACLY ( ortholog_one2one ) Dog_ ACLY ( ortholog_one2one ) GuineaPig_ ACLY ( ortholog_one2one ) Macaque_ ACLY ( ortholog_one2one ) Mouse_ Acly ( ortholog_one2one ) Pig_ ACLY ( ortholog_one2one ) Rat_ Acly ( ortholog_one2one ) Rabbit_ ACLY ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3MWD (X-ray 2.10A ) 3MWE (X-ray 2.20A ) 3PFF (X-ray 2.30A ) 5TDE (X-ray 1.70A ) 5TDF (X-ray 1.80A ) 5TDM (X-ray 2.10A ) 5TDZ (X-ray 2.00A ) 5TE1 (X-ray 2.25A ) 5TEQ (X-ray 2.30A ) 5TES (X-ray 2.40A ) 5TET (X-ray 2.20A ) 6HXH (X-ray 3.30A ) 6HXK (X-ray 1.85A ) 6HXL (X-ray 1.35A ) 6HXM (X-ray 1.30A ) 6O0H (EM 3.67A ) 6POE (EM 3.50A ) 6POF (EM 4.30A ) 6QFB (X-ray 3.25A ) 6UI9 (EM 3.10A ) 6UIA (EM 4.30A ) 6UUW (EM 2.85A ) 6UUZ (EM 3.00A ) 6UV5 (EM 3.40A ) 6Z2H (X-ray 1.80A ) 7LIW (EM 2.85A ) 7LJ9 (EM 3.00A ) 7LLA (EM 2.97A ) |
| DBSNP | rs2304497 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:9116495}. |
| Mouse PG classification | NA |
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