Gene Information
Gene NameACKR4
OrganismHomo sapiens (Human)
Gene Length350
Protein NamesAtypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000129048 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9NPB9
Gene CardACKR4
Uniprot IDQ9NPB9
PfamPF00001
In ASDno
Allosteric Predictionno (-0.508503397)
Ortholog in AnimalsAlpaca_ ACKR4 ( ortholog_one2one )
Dog_ ACKR4 ( ortholog_one2one )
GuineaPig_ ACKR4 ( ortholog_one2one )
Macaque_ ACKR4 ( ortholog_one2one )
Mouse_ Ackr4 ( ortholog_one2one )
Pig_ ACKR4 ( ortholog_one2one )
Rat_ Ackr4 ( ortholog_one2one )
Rabbit_ ACKR4 ( ortholog_one2one )
OhnologsGPR182
ParalogsCCR7, CCR10, CCR9, CXCR6, CCR6, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3
Tissuelung, small.intestine
Tissue SpecificityPredominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. {ECO:0000269|PubMed:10734104, ECO:0000269|PubMed:10767544, ECO:0000269|PubMed:11981810}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447};
Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Mouse PG classificationNA
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