| Gene Information | |
|---|---|
| Gene Name | ACKR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1) |
| Target Name | c-x-c chemokine receptor type 7 |
| Target Type | Preclinical target |
| Gene Age | 645 ( ENSG00000144476 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P25106 |
| Gene Card | ACKR3 |
| Uniprot ID | P25106 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.052968596) |
| Ortholog in Animals | Alpaca_ ACKR3 ( ortholog_one2one ) Dog_ ACKR3 ( ortholog_one2one ) GuineaPig_ ACKR3 ( ortholog_one2one ) Macaque_ ACKR3 ( ortholog_one2one ) Mouse_ Ackr3 ( ortholog_one2one ) Pig_ ACKR3 ( ortholog_one2one ) Rat_ Ackr3 ( ortholog_one2one ) Rabbit_ ACKR3 ( ortholog_one2one ) |
| Ohnologs | CCR2, ACKR2, AGTR2, CCR4, CXCR3 |
| Paralogs | CCR9, CXCR6, CCR7, CCR6, ACKR4, CCR10, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, GALR2, RGR, XCR1 |
| Tissue | NA |
| Tissue Specificity | Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level). {ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:16455976, ECO:0000269|PubMed:19641136, ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389, ECO:0000269|PubMed:21655198}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6K3F (X-ray 2.30A ) 7SK3 (EM 3.80A ) 7SK4 (EM 3.30A ) 7SK5 (EM 4.00A ) 7SK6 (EM 4.00A ) 7SK7 (EM 3.30A ) 7SK8 (EM 3.30A ) 7SK9 (EM 3.70A ) |
| DBSNP | rs10183641 rs200582844 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31211835}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:22457824}. Recycling endosome {ECO:0000269|PubMed:22457824}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. {ECO:0000269|PubMed:22457824}. |
| Mouse PG classification | NA |
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