| Gene Information | |
|---|---|
| Gene Name | ACKR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 336 |
| Protein Names | Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234) |
| Target Name | duffy antigen chemokine receptor |
| Target Type | Successful target |
| Gene Age | 168 ( ENSG00000213088 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q16570 |
| Gene Card | ACKR1 |
| Uniprot ID | Q16570 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.168734678) |
| Ortholog in Animals | Alpaca_ ACKR1 ( ortholog_one2one ) Dog_ ACKR1 ( ortholog_one2one ) GuineaPig_ ACKR1 ( ortholog_one2one ) Macaque_ ACKR1 ( ortholog_one2one ) Mouse_ Ackr1 ( ortholog_one2one ) Pig_ ACKR1 ( ortholog_one2one ) Rat_ Ackr1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4NUU (X-ray 1.95A ) 4NUV (X-ray 2.60A ) 7P93 (X-ray 1.55A ) |
| DBSNP | rs12075 rs34599082 rs13962 rs3027020 rs17851570 |
| Subcellular location [CC] | Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. |
| Mouse PG classification | NA |
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