| Gene Information | |
|---|---|
| Gene Name | ACAT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) |
| Target Name | acetyl-coa acetyltransferase, cytosolic |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120437 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75908 |
| Gene Card | SOAT2 |
| Uniprot ID | O75908 |
| Pfam | PF03062 |
| In ASD | yes |
| Allosteric Prediction | yes (0.654715853) |
| Ortholog in Animals | Alpaca_ ACAT2 ( ortholog_one2one ) Dog_ ACAT2 ( ortholog_one2one ) GuineaPig_ ACAT2 ( ortholog_one2one ) Mouse_ Acat3 ( ortholog_one2many ) Mouse_ Acat2 ( ortholog_one2many ) Pig_ ACAT2 ( ortholog_one2one ) Rat_ Acat2 ( ortholog_one2many ) Rat_ Acat2l1 ( ortholog_one2many ) Rabbit_ ACAT2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACAT1, ACAA2, ACAA1, HADHB |
| Tissue | NA |
| Tissue Specificity | Expression seems confined in hepatocytes and enterocytes. {ECO:0000269|PubMed:16331323}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7N6Q (EM 3.87A ) 7N6R (EM 3.93A ) |
| DBSNP | rs9658625 rs2272296 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O88908}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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