| Gene Information | |
|---|---|
| Gene Name | ACAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) |
| Target Name | acetoacetyl-coa thiolase |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000075239 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P24752 |
| Gene Card | ACAT1 |
| Uniprot ID | P24752 |
| Pfam | PF02803; PF00108 |
| In ASD | no |
| Allosteric Prediction | yes (0.378608723) |
| Ortholog in Animals | Alpaca_ ACAT1 ( ortholog_one2one ) Dog_ ACAT1 ( ortholog_one2one ) GuineaPig_ ACAT1 ( ortholog_one2one ) Mouse_ Acat1 ( ortholog_one2one ) Pig_ ACAT1 ( ortholog_one2one ) Rat_ Acat1 ( ortholog_one2one ) Rabbit_ ACAT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ACAT2, ACAA2, ACAA1, HADHB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001860(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2F2S (X-ray 2.00A ) 2IB7 (X-ray 2.05A ) 2IB8 (X-ray 1.85A ) 2IB9 (X-ray 2.05A ) 2IBU (X-ray 1.90A ) 2IBW (X-ray 1.90A ) 2IBY (X-ray 1.85A ) |
| DBSNP | rs3741056 rs120074145 rs762991875 rs148639841 rs120074141 rs886041122 rs1420321267 rs120074146 rs120074147 rs120074143 rs120074140 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:1979337}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |