| Gene Information | |
|---|---|
| Gene Name | ACAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000072818 ) 3 ( ENSG00000288169 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15027 |
| Gene Card | ACAP1 |
| Uniprot ID | Q15027 |
| Pfam | PF12796; PF01412; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.469914142) |
| Ortholog in Animals | Alpaca_ ACAP1 ( ortholog_one2one ) Dog_ ACAP1 ( ortholog_one2one ) GuineaPig_ ACAP1 ( ortholog_one2one ) Macaque_ ACAP1 ( ortholog_one2one ) Mouse_ Acap1 ( ortholog_one2one ) Pig_ ACAP1 ( ortholog_one2one ) Rat_ Acap1 ( ortholog_one2one ) Rabbit_ ACAP1 ( ortholog_one2one ) |
| Ohnologs | ACAP2, ACAP3 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2 |
| Tissue | appendix, lymph.node, spleen, whole.blood |
| Tissue Specificity | Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. {ECO:0000269|PubMed:11062263}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3JUE (X-ray 2.30A ) 3T9K (X-ray 2.30A ) 4CKG (EM 12.00A ) 4CKH (EM 14.00A ) 4F1P (X-ray 2.30A ) 4NSW (X-ray 2.20A ) 5H3D (EM 14.00A ) |
| DBSNP | rs35933585 rs759855054 rs754740225 rs35019942 |
| Subcellular location [CC] | Recycling endosome membrane {ECO:0000269|PubMed:16256741}; Peripheral membrane protein {ECO:0000269|PubMed:16256741}; Cytoplasmic side {ECO:0000269|PubMed:16256741}. |
| Mouse PG classification | NA |
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