| Gene Information | |
|---|---|
| Gene Name | ACAN |
| Organism | Homo sapiens (Human) |
| Gene Length | 2530 |
| Protein Names | Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2] |
| Target Name | aggrecan core protein |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157766 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P16112 |
| Gene Card | ACAN |
| Uniprot ID | P16112 |
| Pfam | PF00059; PF00084; PF07686; PF00193 |
| In ASD | no |
| Allosteric Prediction | no (-0.131103201) |
| Ortholog in Animals | Alpaca_ ACAN ( ortholog_one2one ) Dog_ ACAN ( ortholog_one2one ) GuineaPig_ ACAN ( ortholog_one2one ) Macaque_ ACAN ( ortholog_one2one ) Mouse_ Acan ( ortholog_one2one ) Pig_ ACAN ( ortholog_one2one ) Rat_ Acan ( ortholog_one2one ) Rabbit_ ACAN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCAN, HAPLN1, NCAN, HAPLN3, VCAN, HAPLN2, HAPLN4 |
| Tissue | aorta, tibial.artery |
| Tissue Specificity | Restricted to cartilages. {ECO:0000269|PubMed:7524681}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4MD4 (X-ray 1.95A ) |
| DBSNP | rs16942318 rs34949187 rs3743398 rs35430524 rs938608 rs938609 rs373544100 rs12899191 rs2882676 rs4932439 rs35061438 rs1042630 rs34153007 rs3817428 rs121913568 rs779794758 rs1126823 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Mouse PG classification | HPG |
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