| Gene Information | |
|---|---|
| Gene Name | CD276 |
| Organism | Homo sapiens (Human) |
| Gene Length | 534 |
| Protein Names | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) |
| Target Name | b7 homolog 3 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000103855 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5ZPR3 |
| Gene Card | CD276 |
| Uniprot ID | Q5ZPR3 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.544561956) |
| Ortholog in Animals | Alpaca_ CD276 ( ortholog_one2one ) Dog_ CD276 ( ortholog_one2one ) Macaque_ CD276 ( ortholog_one2one ) Mouse_ Cd276 ( ortholog_one2one ) Pig_ CD276 ( ortholog_one2one ) Rat_ Cd276 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BTN2A2, BTNL2, BTN2A1, BTNL9, ICOSLG, ERMAP, HHLA2, VTCN1, BTN1A1, BTN3A3, BTN3A2, BTN3A1, MOG, BTNL3, BTNL8 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15961727, ECO:0000269|PubMed:16049332, ECO:0000269|PubMed:16274630}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7173448 rs7173476 rs11574477 rs11574479 rs11574483 rs10083681 rs148625372 rs7173476 rs145827704 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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