Gene Information
Gene NameABL2
OrganismHomo sapiens (Human)
Gene Length1182
Protein NamesTyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
Target Nameabelson tyrosine-protein kinase 2
Target TypeNA
Gene Age886 ( ENSG00000143322 )
Evolutionary StageVertebrata
AlphaFoldDBP42684
Gene CardABL2
Uniprot IDP42684
PfamPF08919; PF07714; PF00017; PF00018
In ASDyes
Allosteric Predictionyes (0.999786171)
Ortholog in AnimalsAlpaca_ ABL2 ( ortholog_one2one )
Dog_ ABL2 ( ortholog_one2one )
GuineaPig_ ABL2 ( ortholog_one2one )
Macaque_ ABL2 ( ortholog_one2one )
Mouse_ Abl2 ( ortholog_one2one )
Pig_ ABL2 ( ortholog_one2one )
Rat_ Abl2 ( ortholog_one2one )
Rabbit_ ABL2 ( ortholog_one2one )
OhnologsABL1
ParalogsABL1, FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, FYN, PTK6
TissueNA
Tissue SpecificityWidely expressed.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001490(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2ECD  (NMR  -  )  2KK1  (NMR  -  )  2XYN  (X-ray  2.81A  )  3GVU  (X-ray  2.05A  )  3HMI  (X-ray  1.65A  )  3ULR  (X-ray  1.65A  )  4EIH  (X-ray  1.20A  )  5NP3  (X-ray  2.00A  )  5NP5  (X-ray  1.40A  ) 
DBSNP rs55655202  rs55892721  rs17277288  rs28913889  rs28913890  rs28913891  rs28913892  rs1318056 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q4JIM5}.
Mouse PG classificationNA
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