| Gene Information | |
|---|---|
| Gene Name | ABL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1130 |
| Protein Names | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) |
| Target Name | abl t315i mutant |
| Target Type | Patented-recorded target |
| Gene Age | 886 ( ENSG00000097007 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P00519 |
| Gene Card | ABL1 |
| Uniprot ID | P00519 |
| Pfam | PF08919; PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.385298391) |
| Ortholog in Animals | Alpaca_ ABL1 ( ortholog_one2many ) Dog_ ABL1 ( ortholog_one2one ) GuineaPig_ ABL1 ( ortholog_one2one ) Macaque_ ABL1 ( ortholog_one2one ) Mouse_ Abl1 ( ortholog_one2one ) Pig_ ABL1 ( ortholog_one2one ) Rat_ Abl1 ( ortholog_one2one ) Rabbit_ ABL1 ( ortholog_one2one ) |
| Ohnologs | ABL2 |
| Paralogs | ABL2, FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001966(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AB2 (NMR - ) 1AWO (NMR - ) 1BBZ (X-ray 1.65A ) 1JU5 (NMR - ) 1OPL (X-ray 3.42A ) 1ZZP (NMR - ) 2ABL (X-ray 2.50A ) 2E2B (X-ray 2.20A ) 2F4J (X-ray 1.91A ) 2FO0 (X-ray 2.27A ) 2G1T (X-ray 1.80A ) 2G2F (X-ray 2.70A ) 2G2H (X-ray 2.00A ) 2G2I (X-ray 3.12A ) 2GQG (X-ray 2.40A ) 2HIW (X-ray 2.20A ) 2HYY (X-ray 2.40A ) 2HZ0 (X-ray 2.10A ) 2HZ4 (X-ray 2.80A ) 2HZI (X-ray 1.70A ) 2O88 (X-ray 1.75A ) 2V7A (X-ray 2.50A ) 3CS9 (X-ray 2.21A ) 3EG0 (X-ray 2.30A ) 3EG1 (X-ray 1.85A ) 3EG2 (X-ray 1.80A ) 3EG3 (X-ray 1.40A ) 3EGU (X-ray 2.25A ) 3K2M (X-ray 1.75A ) 3PYY (X-ray 1.85A ) 3QRI (X-ray 2.10A ) 3QRJ (X-ray 1.82A ) 3QRK (X-ray 2.30A ) 3T04 (X-ray 2.10A ) 3UE4 (X-ray 2.42A ) 3UYO (X-ray 1.83A ) 4J9B (X-ray 1.70A ) 4J9C (X-ray 1.05A ) 4J9D (X-ray 1.50A ) 4J9E (X-ray 1.40A ) 4J9F (X-ray 1.09A ) 4J9G (X-ray 1.80A ) 4J9H (X-ray 1.70A ) 4J9I (X-ray 2.20A ) 4JJB (X-ray 1.65A ) 4JJC (X-ray 1.60A ) 4JJD (X-ray 1.60A ) 4TWP (X-ray 2.40A ) 4WA9 (X-ray 2.20A ) 4XEY (X-ray 2.89A ) 4YC8 (X-ray 2.90A ) 4ZOG (X-ray 2.30A ) 5DC0 (X-ray 2.23A ) 5DC4 (X-ray 1.48A ) 5DC9 (X-ray 1.56A ) 5HU9 (X-ray 1.53A ) 5MO4 (X-ray 2.17A ) 5NP2 (X-ray 1.60A ) 5OAZ (X-ray 1.03A ) 6AMV (NMR - ) 6AMW (NMR - ) 6BL8 (X-ray 2.50A ) 6NPE (X-ray 2.15A ) 6NPU (X-ray 2.33A ) 6NPV (X-ray 1.86A ) 6XR6 (NMR - ) 6XR7 (NMR - ) 6XRG (NMR - ) 7CC2 (X-ray 2.72A ) 7DT2 (X-ray 2.30A ) 7N9G (X-ray 2.20A ) 7W7X (X-ray 2.00A ) 7W7Y (X-ray 2.20A ) |
| DBSNP | rs1064152 rs1060499547 rs34549764 rs1060499548 rs34634745 rs2229071 rs1588283506 rs35266696 rs1064165 rs2229067 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.; [Isoform IB]: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear. |
| Mouse PG classification | NA |
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