| Gene Information | |
|---|---|
| Gene Name | PREX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1659 |
| Protein Names | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000124126 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCU6 |
| Gene Card | PREX1 |
| Uniprot ID | Q8TCU6 |
| Pfam | PF00610; PF00621 |
| In ASD | yes |
| Allosteric Prediction | yes (0.696972096) |
| Ortholog in Animals | Alpaca_ PREX1 ( ortholog_one2one ) Dog_ PREX1 ( ortholog_one2one ) GuineaPig_ PREX1 ( ortholog_one2one ) Macaque_ PREX1 ( ortholog_one2one ) Mouse_ Prex1 ( ortholog_one2one ) Pig_ PREX1 ( ortholog_one2one ) Rat_ Prex1 ( ortholog_one2one ) Rabbit_ PREX1 ( ortholog_one2one ) |
| Ohnologs | PREX2 |
| Paralogs | PREX2, DEPTOR, GPR155 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3QIK (X-ray 2.28A ) 4YON (X-ray 1.95A ) 5D27 (X-ray 1.92A ) 5D3V (X-ray 1.85A ) 5D3W (X-ray 1.85A ) 5D3X (X-ray 1.69A ) 5D3Y (X-ray 1.95A ) 5FI0 (X-ray 3.28A ) 5FI1 (X-ray 3.20A ) 6PCV (EM 3.20A ) 6VSK (X-ray 3.12A ) 7RX9 (X-ray 3.22A ) |
| DBSNP | rs55904123 rs7271583 rs41283558 rs6012504 rs16993997 rs2664521 rs3936192 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane. |
| Mouse PG classification | NA |
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