| Gene Information | |
|---|---|
| Gene Name | ABI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 508 |
| Protein Names | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136754 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IZP0 |
| Gene Card | ABI1 |
| Uniprot ID | Q8IZP0 |
| Pfam | PF07815; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.005248356) |
| Ortholog in Animals | Alpaca_ ABI1 ( ortholog_one2one ) Dog_ ABI1 ( ortholog_one2one ) GuineaPig_ ABI1 ( ortholog_one2one ) Macaque_ ABI1 ( ortholog_one2one ) Mouse_ Abi1 ( ortholog_one2one ) Pig_ ABI1 ( ortholog_one2one ) Rat_ Abi1 ( ortholog_one2one ) Rabbit_ ABI1 ( ortholog_one2one ) |
| Ohnologs | ABI3, ABI2 |
| Paralogs | ABI2, ABI3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:11418237}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.119315(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7LXE (X-ray 1.88A ) |
| DBSNP | rs2306236 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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