| Gene Information | |
|---|---|
| Gene Name | RNF146 |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000118518 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NTX7 |
| Gene Card | RNF146 |
| Uniprot ID | Q9NTX7 |
| Pfam | PF02825 |
| In ASD | no |
| Allosteric Prediction | no (-1.000362206) |
| Ortholog in Animals | Alpaca_ RNF146 ( ortholog_one2one ) Dog_ RNF146 ( ortholog_one2one ) GuineaPig_ RNF146 ( ortholog_one2one ) Macaque_ RNF146 ( ortholog_one2one ) Mouse_ Rnf146 ( ortholog_one2one ) Pig_ RNF146 ( ortholog_one2one ) Rat_ Rnf146 ( ortholog_one2one ) Rabbit_ RNF146 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002166(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D8T (NMR - ) 3V3L (X-ray 1.65A ) 6CF6 (X-ray 1.93A ) |
| DBSNP | rs10081141 |
| Subcellular location [CC] | Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding. |
| Mouse PG classification | NA |
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