Gene Information
Gene NameGSTO1
OrganismHomo sapiens (Human)
Gene Length241
Protein NamesGlutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)
Target Nameglutathione s-transferase omega-1
Target TypeNA
Gene Age454 ( ENSG00000148834 )
Evolutionary StageEuk+Bac
AlphaFoldDBP78417
Gene CardGSTO1
Uniprot IDP78417
PfamPF14497; PF13417
In ASDno
Allosteric Predictionyes (0.380186069)
Ortholog in AnimalsAlpaca_ GSTO1 ( ortholog_one2one )
Dog_ GSTO1 ( ortholog_one2one )
GuineaPig_ GSTO1 ( ortholog_one2one )
Mouse_ Gsto1 ( ortholog_one2one )
Pig_ GSTO1 ( ortholog_one2many )
Rat_ Gsto1 ( ortholog_one2one )
Rabbit_ GSTO1 ( ortholog_one2one )
OhnologsNA
ParalogsCLIC2, GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, CLIC4, GSTT2, GSTT2B, CLIC1, EEF1G, GDAP1, CLIC6, CLIC5
TissueNA
Tissue SpecificityUbiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. {ECO:0000269|PubMed:10783391}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.008324(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1EEM  (X-ray  2.00A  )  3LFL  (X-ray  2.10A  )  3VLN  (X-ray  1.70A  )  4IS0  (X-ray  1.72A  )  4YQM  (X-ray  2.38A  )  4YQU  (X-ray  1.94A  )  4YQV  (X-ray  2.06A  )  5UEH  (X-ray  2.00A  )  5V3Q  (X-ray  2.25A  )  5YVN  (X-ray  1.33A  )  5YVO  (X-ray  1.80A  )  6MHB  (X-ray  2.75A  )  6MHC  (X-ray  2.00A  )  6MHD  (X-ray  2.16A  )  6PNM  (X-ray  1.82A  )  6PNN  (X-ray  2.10A  )  6PNO  (X-ray  1.82A  ) 
DBSNP rs45529437  rs11509436  rs4925  rs11509438  rs11509439 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:11511179}.
Mouse PG classificationNA
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