| Gene Information | |
|---|---|
| Gene Name | ABHD5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 349 |
| Protein Names | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC 2.3.1.51) (Abhydrolase domain-containing protein 5) (Lipid droplet-binding protein CGI-58) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000011198 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8WTS1 |
| Gene Card | ABHD5 |
| Uniprot ID | Q8WTS1 |
| Pfam | PF00561 |
| In ASD | no |
| Allosteric Prediction | no (-0.727770382) |
| Ortholog in Animals | Alpaca_ ABHD5 ( ortholog_one2one ) Dog_ ABHD5 ( ortholog_one2one ) GuineaPig_ ABHD5 ( ortholog_one2one ) Macaque_ ABHD5 ( ortholog_one2one ) Mouse_ Abhd5 ( ortholog_one2one ) Pig_ ABHD5 ( ortholog_one2one ) Rat_ Abhd5 ( ortholog_one2one ) Rabbit_ ABHD5 ( ortholog_one2one ) |
| Ohnologs | ABHD4 |
| Paralogs | SERHL2, MEST, EPHX4, ABHD6, ABHD8, ABHD11, EPHX2, ABHD14B, BPHL, ABHD14A, EPHX3, ABHD4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level). {ECO:0000269|PubMed:11590543, ECO:0000269|PubMed:18832586}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs104893676 rs2302349 rs145548259 rs28939077 rs28939078 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18832586}. Lipid droplet {ECO:0000250|UniProtKB:Q9DBL9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9DBL9}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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