| Gene Information | |
|---|---|
| Gene Name | TACR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) |
| Target Name | substance-k receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000075073 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21452 |
| Gene Card | TACR2 |
| Uniprot ID | P21452 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000433338) |
| Ortholog in Animals | Alpaca_ TACR2 ( ortholog_one2one ) Dog_ TACR2 ( ortholog_one2one ) GuineaPig_ TACR2 ( ortholog_one2one ) Macaque_ TACR2 ( ortholog_one2one ) Mouse_ Tacr2 ( ortholog_one2one ) Pig_ TACR2 ( ortholog_one2one ) Rat_ Tacr2 ( ortholog_one2one ) Rabbit_ TACR2 ( ortholog_one2one ) |
| Ohnologs | TACR1, TACR3 |
| Paralogs | OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | esophagus, smooth.muscle, sigmoid.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs5030920 rs57500981 rs55953810 rs57900755 rs2229170 rs58692969 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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