| Gene Information | |
|---|---|
| Gene Name | ANK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1881 |
| Protein Names | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000029534 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P16157 |
| Gene Card | ANK1 |
| Uniprot ID | P16157 |
| Pfam | PF00023; PF12796; PF13637; PF00531; PF17809; PF00791 |
| In ASD | no |
| Allosteric Prediction | yes (0.502411844) |
| Ortholog in Animals | Alpaca_ ANK1 ( ortholog_one2one ) Dog_ ANK1 ( ortholog_one2one ) GuineaPig_ ANK1 ( ortholog_one2one ) Macaque_ ANK1 ( ortholog_one2one ) Mouse_ Ank1 ( ortholog_one2one ) Pig_ ANK1 ( ortholog_one2one ) Rat_ Ank1 ( ortholog_one2one ) Rabbit_ ANK1 ( ortholog_one2one ) |
| Ohnologs | ANK3, ANK2 |
| Paralogs | ANK2, ASB7, ANK3 |
| Tissue | bone.marrow, heart, skeletal.muscle, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain. {ECO:0000269|PubMed:9430667}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1N11 (X-ray 2.70A ) 2YQF (NMR - ) 2YVI (X-ray 1.92A ) 3F59 (X-ray 2.00A ) 3KBT (X-ray 2.75A ) 3KBU (X-ray 2.75A ) 3UD1 (X-ray 2.00A ) 3UD2 (X-ray 2.21A ) 7TW3 (EM 4.40A ) 7TW5 (EM 5.70A ) 7TW6 (EM 5.60A ) 7UZQ (EM 2.17A ) 7UZU (EM 2.30A ) 7V0K (EM 2.40A ) 7V0M (EM 2.70A ) 7V0S (EM 2.50A ) 7V0X (EM 3.00A ) 8CS9 (EM 2.74A ) 8CSL (EM 25.00A ) 8CSV (EM 2.70A ) 8CTE (EM 2.90A ) |
| DBSNP | rs140085544 rs2304877 rs11778936 rs34523608 rs758454168 rs35213384 rs504465 rs486770 rs10093583 rs1060130 rs1457291305 |
| Subcellular location [CC] | [Isoform Er1]: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; [Isoform Mu18]: Sarcoplasmic reticulum {ECO:0000305}.; [Isoform Mu19]: Sarcoplasmic reticulum {ECO:0000305}.; [Isoform Mu20]: Sarcoplasmic reticulum {ECO:0000305}. |
| Mouse PG classification | HPG |
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