Gene Information
Gene NameABCG2
OrganismHomo sapiens (Human)
Gene Length655
Protein NamesBroad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)
Target Nameatp-binding cassette transporter g2
Target TypeSuccessful target
Gene Age8 ( ENSG00000118777 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9UNQ0
Gene CardABCG2
Uniprot IDQ9UNQ0
PfamPF01061; PF19055; PF00005
In ASDyes
Allosteric Predictionyes (0.999989268)
Ortholog in AnimalsAlpaca_ ABCG2 ( ortholog_one2one )
Dog_ ABCG2 ( ortholog_one2one )
Mouse_ Abcg3 ( ortholog_one2one )
Pig_ ABCG2 ( ortholog_one2many )
Rat_ Abcg3 ( ortholog_one2many )
Rat_ Abcg3l2 ( ortholog_one2many )
Rat_ Abcg3l3 ( ortholog_one2many )
Rat_ Abcg3l1 ( ortholog_one2many )
Rat_ Abcg3l4 ( ortholog_one2many )
OhnologsNA
ParalogsABCG8, ABCG5, ABCG4, ABCG1
TissueNA
Tissue SpecificityHighly expressed in placenta (PubMed:9850061). Low expression in small intestine, liver and colon (PubMed:9861027). Expressed in brain (at protein level) (PubMed:12958161). {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:9850061, ECO:0000269|PubMed:9861027}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5NJ3  (EM  3.78A  )  5NJG  (EM  3.78A  )  6ETI  (EM  3.10A  )  6FEQ  (EM  3.60A  )  6FFC  (EM  3.56A  )  6HBU  (EM  3.09A  )  6HCO  (EM  3.58A  )  6HIJ  (EM  3.56A  )  6HZM  (EM  3.09A  )  6VXF  (EM  3.50A  )  6VXH  (EM  4.00A  )  6VXI  (EM  3.70A  )  6VXJ  (EM  4.10A  )  7NEQ  (EM  3.12A  )  7NEZ  (EM  3.39A  )  7NFD  (EM  3.51A  )  7OJ8  (EM  3.40A  )  7OJH  (EM  3.10A  )  7OJI  (EM  3.40A  ) 
DBSNP rs2231137  rs1319203095  rs2231142  rs372192400  rs753759474  rs528655917  rs1061017  rs12721643  rs1061018  rs3116448  rs41282401  rs138606116  rs752626614  rs199854112  rs769734146  rs1354553769  rs1274428653  rs192169063  rs45605536  rs9282571  rs200894058  rs34264773  rs34783571 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:15769853, ECO:0000269|PubMed:15807535, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252};
Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181};
Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.
Mouse PG classificationNA
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