| Gene Information | |
|---|---|
| Gene Name | KDM5D |
| Organism | Homo sapiens (Human) |
| Gene Length | 1539 |
| Protein Names | Lysine-specific demethylase 5D (EC 1.14.11.67) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY) ([histone H3]-trimethyl-L-lysine(4) demethylase 5D) |
| Target Name | lysine-specific demethylase 5d |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000012817 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BY66 |
| Gene Card | KDM5D |
| Uniprot ID | Q9BY66 |
| Pfam | PF01388; PF02373; PF02375; PF00628; PF08429; PF02928 |
| In ASD | no |
| Allosteric Prediction | no (-0.324924861) |
| Ortholog in Animals | Alpaca_ KDM5D ( ortholog_one2one ) Macaque_ KDM5D ( ortholog_one2one ) Mouse_ Kdm5d ( ortholog_one2one ) Pig_ KDM5D ( ortholog_one2one ) Rat_ Kdm5d ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | JARID2, KDM4C, KDM4F, KDM4E, KDM4B, KDM4D, KDM5B, KDM4A, KDM5A, KDM5C |
| Tissue | NA |
| Tissue Specificity | Expression is highly down-regulated in metastatic prostate tumors. {ECO:0000269|PubMed:26747897}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E6R (NMR - ) 2YQE (NMR - ) |
| DBSNP | rs1050807 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27185910, ECO:0000269|PubMed:27477906, ECO:0000305}. |
| Mouse PG classification | NA |
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