Gene Information
Gene NameABCC4
OrganismHomo sapiens (Human)
Gene Length1325
Protein NamesATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)
Target Namemultidrug resistance-associated protein 4
Target TypeNA
Gene Age1064 ( ENSG00000125257 )
Evolutionary StageEukaryota
AlphaFoldDBO15439
Gene CardABCC4
Uniprot IDO15439
PfamPF00664; PF00005
In ASDyes
Allosteric Predictionyes (1.000042825)
Ortholog in AnimalsAlpaca_ ABCC4 ( ortholog_one2one )
Dog_ ABCC4 ( ortholog_one2one )
GuineaPig_ ABCC4 ( ortholog_one2one )
Macaque_ ABCC4 ( ortholog_one2one )
Mouse_ Abcc4 ( ortholog_one2one )
Rat_ Abcc4 ( ortholog_one2one )
Rabbit_ ABCC4 ( ortholog_one2one )
OhnologsNA
ParalogsABCC1, ABCC8, ABCC3, ABCC10, ABCC9, ABCC5, ABCC6, ABCC12, CFTR, ABCC2, ABCC11
TissueNA
Tissue SpecificityWidely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11568681  rs11568689  rs4148460  rs45454092  rs11568658  rs11568684  rs2274407  rs11568701  rs11568705  rs11568668  rs11568669  rs753414892  rs11568699  rs11568697  rs9282570  rs3765534  rs146708960  rs11568659  rs11568694  rs45477596  rs139970608  rs45504892  rs11568644 
Subcellular location [CC]Basolateral cell membrane {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:26721430};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:26721430};
Multi-pass membrane protein {ECO:0000255}. Note=Its localization to the basolateral or apical membranes is tissue-dependent. {ECO:0000305|PubMed:26721430}.
Mouse PG classificationNA
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