| Gene Information | |
|---|---|
| Gene Name | ABCC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1531 |
| Protein Names | Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter) |
| Target Name | multidrug resistance-associated protein 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000103222 ) 3 ( ENSG00000278183 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P33527 |
| Gene Card | ABCC1 |
| Uniprot ID | P33527 |
| Pfam | PF00664; PF00005 |
| In ASD | yes |
| Allosteric Prediction | yes (1.060737251) |
| Ortholog in Animals | Alpaca_ ABCC1 ( ortholog_one2one ) Dog_ ABCC1 ( ortholog_one2one ) GuineaPig_ ABCC1 ( ortholog_one2one ) Macaque_ ABCC1 ( ortholog_one2one ) Mouse_ Abcc1 ( ortholog_one2one ) Pig_ ABCC1 ( ortholog_one2one ) Rat_ Abcc1 ( ortholog_one2one ) Rabbit_ ABCC1 ( ortholog_one2one ) |
| Ohnologs | ABCC3 |
| Paralogs | ABCC8, ABCC3, ABCC10, ABCC9, ABCC5, ABCC6, ABCC4, ABCC12, CFTR, ABCC2, ABCC11 |
| Tissue | NA |
| Tissue Specificity | Lung, testis and peripheral blood mononuclear cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CBZ (X-ray 1.50A ) 4C3Z (X-ray 2.10A ) |
| DBSNP | rs41395947 rs41494447 rs60782127 rs112282109 rs45511401 rs4148356 rs45517537 rs13337489 rs41410450 rs28706727 rs369410659 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16230346, ECO:0000269|PubMed:31273342}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346}. |
| Mouse PG classification | NA |
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