Gene Information
Gene NameABCB1
OrganismHomo sapiens (Human)
Gene Length1280
Protein NamesATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243)
Target Namemultidrug resistance protein 1
Target TypeSuccessful target
Gene Age382 ( ENSG00000085563 )
Evolutionary StageEuk+Bac
AlphaFoldDBP08183
Gene CardABCB1
Uniprot IDP08183
PfamPF00664; PF00005
In ASDyes
Allosteric Predictionyes (1.353063163)
Ortholog in AnimalsAlpaca_ ABCB1 ( ortholog_one2one )
Dog_ ABCB1 ( ortholog_one2one )
GuineaPig_ Abcb1 ( ortholog_one2many )
Mouse_ Abcb1a ( ortholog_one2many )
Mouse_ Abcb1b ( ortholog_one2many )
Rat_ Abcb1b ( ortholog_one2many )
Rabbit_ ABCB1 ( ortholog_one2one )
OhnologsABCB11
ParalogsABCB6, TAP1, ABCB11, ABCB4, ABCB9, ABCB8, TAP2, ABCB7, ABCB10, ABCB5
Tissueadrenal.gland
Tissue SpecificityExpressed in small intestine (PubMed:28408210). Expressed in liver, kidney and brain. {ECO:0000269|PubMed:28408210}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6C0V  (EM  3.40A  )  6FN1  (EM  3.58A  )  6FN4  (EM  4.14A  )  6QEX  (EM  3.60A  )  7A65  (EM  3.90A  )  7A69  (EM  3.20A  )  7A6C  (EM  3.60A  )  7A6E  (EM  3.60A  )  7A6F  (EM  3.50A  )  7O9W  (EM  3.50A  ) 
DBSNP rs28381804  rs9282564  rs1202183  rs9282565  rs1128501  rs36008564  rs2229109  rs28381902  rs28381914  rs2235036  rs35023033  rs2235039  rs2032581  rs28381967  rs2032582  rs2032582  rs926081975  rs72552784  rs28401798  rs55852620  rs2229107  rs28364274 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:35970996};
Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). {ECO:0000269|PubMed:35970996}.
Mouse PG classificationNA
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