Gene Information
Gene NameWDFY3
OrganismHomo sapiens (Human)
Gene Length3526
Protein NamesWD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000163625 )
Evolutionary StageEukaryota
AlphaFoldDBNA
Gene CardWDFY3
Uniprot IDQ8IZQ1
PfamPF02138; PF01363; PF14844
In ASDno
Allosteric Predictionno (-0.608751796)
Ortholog in AnimalsAlpaca_ WDFY3 ( ortholog_one2one )
Dog_ WDFY3 ( ortholog_one2one )
GuineaPig_ WDFY3 ( ortholog_one2one )
Macaque_ WDFY3 ( ortholog_one2one )
Mouse_ Wdfy3 ( ortholog_one2one )
Pig_ WDFY3 ( ortholog_one2one )
Rat_ Wdfy3 ( ortholog_one2one )
Rabbit_ WDFY3 ( ortholog_one2one )
OhnologsWDFY4
ParalogsNBEA, WDFY4, LYST, NBEAL1, NBEAL2, LRBA, NSMAF
TissueNA
Tissue SpecificityExpressed in osteoclast and their mononuclear precursors (at protein level). {ECO:0000269|PubMed:20971078}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.0375(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3WIM  (X-ray  2.60A  )  6W9N  (NMR  -  ) 
DBSNP rs1553924800  rs17368018 
Subcellular location [CC]Nucleus membrane {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Cytoplasm, cytosol {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Membrane;
Peripheral membrane protein {ECO:0000269|PubMed:15292400};
Cytoplasmic side {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q6VNB8}. Cell projection, axon {ECO:0000250|UniProtKB:Q6VNB8}. Note=Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures (PubMed:15292400, PubMed:20168092, PubMed:20971078, PubMed:20417604). This redistribution is dependent on p62/SQSTM1 (PubMed:20168092). When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (PubMed:20168092). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (By similarity). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}.
Mouse PG classificationNA
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