Gene Information
Gene NameABCA1
OrganismHomo sapiens (Human)
Gene Length2261
Protein NamesPhospholipid-transporting ATPase ABCA1 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 1) (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
Target Nameatp-binding cassette transporter a1
Target TypeSuccessful target
Gene Age1488 ( ENSG00000165029 )
Evolutionary StageEuk+Bac
AlphaFoldDBO95477
Gene CardABCA1
Uniprot IDO95477
PfamPF00005
In ASDyes
Allosteric Predictionyes (1.574542521)
Ortholog in AnimalsAlpaca_ ABCA1 ( ortholog_one2one )
Dog_ ABCA1 ( ortholog_one2one )
GuineaPig_ ABCA1 ( ortholog_one2one )
Macaque_ ABCA1 ( ortholog_one2one )
Mouse_ Abca1 ( ortholog_one2one )
Pig_ ABCA1 ( ortholog_one2one )
Rat_ Abca1 ( ortholog_one2one )
Rabbit_ ABCA1 ( ortholog_one2one )
OhnologsABCA7, ABCA2, ABCA4
ParalogsABCA5, ABCA9, ABCA12, ABCA7, ABCA8, ABCA13, ABCA3, ABCA2, ABCA6, ABCA10, ABCA4
TissueNA
Tissue SpecificityWidely expressed, but most abundant in macrophages.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5XJY  (EM  4.10A  )  7ROQ  (EM  4.10A  ) 
DBSNP rs145183203  rs2230806  rs9282541  rs142625938  rs758100110  rs775035559  rs9282543  rs138487227  rs147675550  rs2853574  rs137854496  rs137854496  rs2853578  rs374190304  rs2066718  rs35819696  rs138880920  rs145582736  rs2066715  rs1322998567  rs2066714  rs28937314  rs28937313  rs137854495  rs141021096  rs13306072  rs745593394  rs28933692  rs33918808  rs76881554  rs562403512  rs137854500  rs147743782  rs145689805  rs189206655  rs137854494  rs137854497  rs1997618  rs2230808  rs1251839800  rs1883024  rs1203589782  rs150125857  rs137854498  rs760507032  rs146292819  rs1055285452  rs760768125  rs142688906  rs137854499  rs137854501  rs369098049  rs2853577  rs564764153  rs34879708  rs144588452 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:19258317, ECO:0000269|PubMed:19556522, ECO:0000269|PubMed:24097981};
Multi-pass membrane protein {ECO:0000305|PubMed:19258317}. Endosome {ECO:0000269|PubMed:24097981}.
Mouse PG classificationNA
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