| Gene Information | |
|---|---|
| Gene Name | ABC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 678 |
| Protein Names | ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P45844 |
| Gene Card | ABCG1 |
| Uniprot ID | P45844 |
| Pfam | PF01061; PF19055; PF00005 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269|PubMed:11350058}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7FDV (EM 3.26A ) 7OZ1 (EM 4.00A ) 7R8C (EM 3.70A ) 7R8D (EM 3.20A ) 7R8E (EM 3.68A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Golgi apparatus membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Cell membrane {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:24576892}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. |
| Mouse PG classification | NA |
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