| Gene Information | |
|---|---|
| Gene Name | OLFM4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 510 |
| Protein Names | Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000102837 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UX06 |
| Gene Card | OLFM4 |
| Uniprot ID | Q6UX06 |
| Pfam | PF02191 |
| In ASD | no |
| Allosteric Prediction | no (-0.530446259) |
| Ortholog in Animals | Alpaca_ OLFM4 ( ortholog_one2one ) Dog_ OLFM4 ( ortholog_one2one ) GuineaPig_ OLFM4 ( ortholog_one2one ) Macaque_ OLFM4 ( ortholog_one2one ) Mouse_ Olfm4 ( ortholog_one2one ) Pig_ OLFM4 ( ortholog_one2one ) Rat_ Olfm4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OLFML1, OLFM2, OLFM3, OLFM1, OLFML2B, GLDN, MYOC, OLFML3, OLFML2A |
| Tissue | small.intestine.Peyers.patch |
| Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. {ECO:0000269|PubMed:11867215, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35790097 |
| Subcellular location [CC] | Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}. |
| Mouse PG classification | NA |
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