| Gene Information | |
|---|---|
| Gene Name | PRDX4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 271 |
| Protein Names | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000123131 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13162 |
| Gene Card | PRDX4 |
| Uniprot ID | Q13162 |
| Pfam | PF10417; PF00578 |
| In ASD | no |
| Allosteric Prediction | no (-0.335185095) |
| Ortholog in Animals | Alpaca_ PRDX4 ( ortholog_one2one ) Dog_ PRDX4 ( ortholog_one2one ) GuineaPig_ PRDX4 ( ortholog_one2one ) Macaque_ PRDX4 ( ortholog_one2one ) Mouse_ Prdx4 ( ortholog_one2one ) Pig_ PRDX4 ( ortholog_one2one ) Rat_ Prdx4 ( ortholog_one2one ) Rabbit_ PRDX4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRDX1, PRDX6, PRDX2, PRDX3 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2PN8 (X-ray 1.80A ) 3TJB (X-ray 2.38A ) 3TJF (X-ray 2.04A ) 3TJG (X-ray 2.24A ) 3TJJ (X-ray 1.91A ) 3TJK (X-ray 2.09A ) 3TKP (X-ray 2.49A ) 3TKQ (X-ray 2.22A ) 3TKR (X-ray 2.10A ) 3TKS (X-ray 2.40A ) 4RQX (X-ray 2.26A ) 5HQP (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18052930, ECO:0000269|PubMed:9388242}. Endoplasmic reticulum {ECO:0000269|PubMed:18052930}. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic. {ECO:0000269|PubMed:18052930}. |
| Mouse PG classification | NA |
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