| Gene Information | |
|---|---|
| Gene Name | A2ML1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1454 |
| Protein Names | Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000166535 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | A8K2U0 |
| Gene Card | A2ML1 |
| Uniprot ID | A8K2U0 |
| Pfam | PF00207; PF07703; PF07677; PF01835; PF17791; PF17789; PF07678 |
| In ASD | no |
| Allosteric Prediction | no (-0.809700821) |
| Ortholog in Animals | Alpaca_ A2ML1 ( ortholog_one2one ) Dog_ A2ML1 ( ortholog_one2one ) Macaque_ A2ML1 ( ortholog_one2one ) Pig_ A2ML1 ( ortholog_one2one ) Rabbit_ A2ML1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPAMD8, A2M, C3, CD109, PZP, C5, C4B, C4A |
| Tissue | esophagus, esophagus.mucosa |
| Tissue Specificity | In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon. {ECO:0000269|PubMed:16298998}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7Q1Y (X-ray 4.40A ) 7Q5Z (EM 3.25A ) 7Q60 (EM 3.13A ) 7Q61 (EM 2.88A ) 7Q62 (EM 3.18A ) |
| DBSNP | rs11047499 rs192888493 rs863224953 rs1860926 rs1558526 rs201725377 rs1860967 rs7959680 rs10219561 rs7308811 rs201083574 rs7315591 rs863224955 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:16298998}. |
| Mouse PG classification | NA |
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