| Gene Information | |
|---|---|
| Gene Name | A2M |
| Organism | Homo sapiens (Human) |
| Gene Length | 1474 |
| Protein Names | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) |
| Target Name | alpha-2-macroglobulin |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000175899 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P01023 |
| Gene Card | A2M |
| Uniprot ID | P01023 |
| Pfam | PF00207; PF07703; PF07677; PF01835; PF17791; PF17789; PF07678 |
| In ASD | no |
| Allosteric Prediction | yes (1.329972385) |
| Ortholog in Animals | Alpaca_ A2M ( ortholog_one2one ) Dog_ A2M ( ortholog_one2one ) GuineaPig_ A2M ( ortholog_one2one ) Mouse_ A2m ( ortholog_one2one ) Pig_ A2M ( ortholog_one2one ) Rat_ A2m ( ortholog_one2one ) Rabbit_ A2M ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CPAMD8, C3, A2ML1, CD109, PZP, C5, C4B, C4A |
| Tissue | NA |
| Tissue Specificity | Secreted in plasma. {ECO:0000269|PubMed:6203908}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BV8 (NMR - ) 2P9R (X-ray 2.30A ) 6TAV (X-ray 4.20A ) 7O7L (EM 4.50A ) 7O7M (EM 6.60A ) 7O7N (EM 7.30A ) 7O7O (EM 4.80A ) 7O7P (EM 4.60A ) 7O7Q (EM 3.60A ) 7O7R (EM 3.90A ) 7O7S (EM 4.30A ) |
| DBSNP | rs226405 rs1800434 rs3180392 rs1800433 rs669 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:6203908}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |