| Gene Information | |
|---|---|
| Gene Name | A1CF |
| Organism | Homo sapiens (Human) |
| Gene Length | 594 |
| Protein Names | APOBEC1 complementation factor (APOBEC1-stimulating protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000148584 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NQ94 |
| Gene Card | A1CF |
| Uniprot ID | Q9NQ94 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.467881292) |
| Ortholog in Animals | Alpaca_ A1CF ( ortholog_one2one ) Dog_ A1CF ( ortholog_one2one ) GuineaPig_ A1CF ( ortholog_one2one ) Macaque_ A1CF ( ortholog_one2one ) Mouse_ A1cf ( ortholog_one2one ) Pig_ A1CF ( ortholog_one2one ) Rat_ A1cf ( ortholog_one2one ) Rabbit_ A1CF ( ortholog_one2one ) |
| Ohnologs | RBM46 |
| Paralogs | RBM46, RBM19, MSI2, HNRNPA1L2, HNRNPA1L3, HNRNPA1, RBM39, RBM23, TIAL1, DAZAP1, RBMX, RBMXL1, HNRNPA0, HNRNPAB, CIRBP, RBM3, HNRNPA3, RBMY1D, RBMY1B, RBMY1A1, RBMY1J, RBMY1F, RBMY1E, MSI1, RBM47, TRNAU1AP, HNRNPA2B1, RBMXL2, RBMXL3, RBM4, RBM4B, HNRNPD, DND1, NCL, HNRNPDL, TIA1 |
| Tissue | liver, kidney, pancreas, small.intestine |
| Tissue Specificity | Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CPD (NMR - ) |
| DBSNP | rs9073 rs11817448 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}. |
| Mouse PG classification | NA |
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