| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| vortioxetine | beta-1 adrenergic receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
NA | approved,investigational | ligand |
| vortioxetine | 5-hydroxytryptamine receptor 1a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.27 | approved,investigational | agonist |
| vortioxetine | 5-hydroxytryptamine receptor 1b | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.33 | approved,investigational | partial agonist |
| vortioxetine | 5-hydroxytryptamine receptor 1b | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.33 | approved,investigational | partial agonist,agonist |
| vortioxetine | 5-hydroxytryptamine receptor 3a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.32 | approved,investigational | antagonist |
| vortioxetine | 5-hydroxytryptamine receptor 7 | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.44 | approved,investigational | antagonist |
| vortioxetine | sodium-dependent noradrenaline transporter | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
NA | approved,investigational | blocker |
| vortioxetine | serotonin transporter | NA | Successful target | TTD , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.36 | approved | inhibitor |
| vortioxetine | sodium-dependent serotonin transporter | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.36 | approved,investigational | inhibitor |
| vortioxetine | serotonin transporter | NA | Successful target | TTD , DGIDB | Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mood Disorders[MeSHID:D019964] |
0.36 | approved | unknown |
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